Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines

F Johnson, KMR Pillai, AP Grollman…

Index: Johnson; Pillai; Grollman; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 954 - 958

Full Text: HTML

Citation Number: 47

Abstract

1 ously.'The general method gives good yields and was used for the synthesis of a series of the related pyrimidine derivatives (7, 8, and 10-14). A modified variation of this procedure was used for the synthesis of the cytosine propenal compound 2. Compounds 12 and 13 were prepared by substituting cyanoacetylene or l-butyn-3-one, respectively, for 2-propynal in the reaction. The reduction product (15) of 1 was prepared by using sodium ...

Related Articles:

Synthesis and antiviral activity of new unsaturated pyrimidine acyclonucleosides

[Ozerov, A. A.; Novikov, M. S.; Brel', A. K.; Andreeva, O. T.; Vladykov, G. V.; et al. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 8 p. 560 - 565 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 8 p. 44 - 47]

Abundance of Four Sulfur Mustard-DNA Adducts ex Vivo and in Vivo Revealed by Simultaneous Quantification in Stable Isotope Dilution–Ultrahigh Performance …

[Gundersen, Lise-Lotte; Benneche, Tore; Rise, Frode; Gogoll, Adolf; Undheim, Kjell Acta Chemica Scandinavica, 1992 , vol. 46, # 8 p. 761 - 771]

Synthesis of 1-(3-azido-2, 3-dideoxy-beta-D-ribo-hexofuranosyl) thymine

[Almond; Lowen; Martin; Rideout Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 905 - 913]

More Articles...