Synthesis of 1-(3-azido-2, 3-dideoxy-beta-D-ribo-hexofuranosyl) thymine

MR Almond, GT Lowen, GE Martin…

Index: Almond; Lowen; Martin; Rideout Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 905 - 913

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Abstract

Abstract The nucleoside derivative 1-(3-azido-2, 3-dideoxy-beta-D-ribo-hexofuranosyl) thymine has been synthesized from 3-0-benzyl-1, 2-0-isopropylidene-alpha-D- glucofuranose-5, 6-carbonate in an overall yield of 16%. The key step in the synthesis involves the selective deacetylation of a nucleoside derivative having a cyclic carbonate moiety.

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