Microwave??Assisted Solution??Phase Synthesis of 1, 4, 5??Trisubstituted Pyrazoles

G Giacomelli, A Porcheddu, M Salaris…

Index: Giacomelli, Giampaolo; Porcheddu, Andrea; Salaris, Margherita; Taddei, Maurizio European Journal of Organic Chemistry, 2003 , # 3 p. 537 - 541

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Citation Number: 30

Abstract

Abstract A small parallel library of 1, 4, 5-trisubstituted pyrazoles was prepared in solution using a three-step procedure starting from Meldrum acid. The Meldrum acid was acylated with different acyl chlorides and the products opened with different alcohols and amines to give substituted β-keto esters and β-keto amines. Further reaction with N, N- dimethylformamide dimethylacetal and the final cyclisation were effectively carried out ...