Tetrahedron letters

A concise synthesis of 7-chloro-2-methylsulfanyl-thiazolo [4, 5-b] pyridine-6-carbonitrile, a versatile intermediate for substituted 6-cyanothiazolopyridines

SG Johnson, PJ Connolly, WV Murray

Index: Johnson, Sigmond G.; Connolly, Peter J.; Murray, William V. Tetrahedron Letters, 2006 , vol. 47, # 28 p. 4853 - 4856

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Citation Number: 13

Abstract

In support of kinase target directed projects we sought to synthesize substituted 6-cyanothiazolopyridines devoid of substitution on the C-5 position, 1. Surprisingly, there are no published literature procedures for making such compounds. Furthermore, there are few examples of 6-cyanothiazolo[4,5-b]pyridines with substitution on the C-5 position. Common synthetic routes involve pyridine ring formation through either intramolecular cyclization onto one of the cyano groups of a malonitrile ...