Synlett

1-tert-Butyl-1H-tetrazol-5-yl sulfones in the modified Julia olefination

PJ Kocienski, A Bell, PR Blakemore

Index: Kocienski, Philip J.; Bell, Alan; Blakemore, Paul R. Synlett, 2000 , # 3 p. 365 - 366

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Citation Number: 63

Abstract

Abstract: The improved stability of metallated 1-tert-butyl-1H-tet- razol-5-yl sulfones enhances the scope and efficiency of the modi- fied Julia olefination. 1-tert-Butyl-1H-tetrazol-5-yl sulfones further stabilised by benzylic or allylic conjugation give alkenes with high (Z)-selectivity. Key words: Julia olefination, fragment linkage, sulfone, (Z)-selec- tivity ... Julia and co-workers invented a one-pot olefination reac- tion based on the condensation of metallated heterocyclic ...