Synthetic approaches and total synthesis of natural zoapatanol

…, B Gille, V Bellosta, J Cossy

Index: Taillier, Catherine; Gille, Barbara; Bellosta, Veronique; Cossy, Janine Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2097 - 2108

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Citation Number: 50

Abstract

The total synthesis of (+)-zoapatanol utilizing an intramolecular Horner-Wadsworth-Emmons olefination and an enantioselective Sharpless dihydroxylation as the key steps has been achieved. An advanced oxepene intermediate has been obtained by applying a ring-closing metathesis to an unsaturated enol ether.