Potential cerebral perfusion agents. Synthesis and evaluation of new radioiodinated barbituric acid analogs

PC Srivastava, CE Guyer…

Index: Srivastava; Guyer; Knapp Jr. Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1081 - 1084

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Citation Number: 7

Abstract

Abstract Two new 125 I-labeled barbituric acid analogs, 5-ethyl-5-(E-1-iodo-1-penten-5-yl) 2- thiobarbituric acid (4) and 5-ethyl-5-(m-iodophenyl) barbituric acid (7), have been prepared and evaluated in rats as potential cerebral perfusion agents. Annulation of 2-ethyl-2-(E-1-