Journal of Heterocyclic Chemistry

Reaction of 2??acetamido??3, 7??dihydropyrrolo [2, 3??d] pyrimidin??4??one with dimethylamine and formaldehyde. Formation of two isomeric mannich bases

E Benghiat, PA Crooks

Index: Benghiat, Eric; Crooks, Peter A. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1023 - 1025

Full Text: HTML

Citation Number: 8

Abstract

Abstract 2-Acetamido-3, 7-dihydropyrrolo [2, 3-d) pyrimidin-4-one reacts with dimethylamine and formaldehyde in glacial acetic acid to afford the two isomeric Mannich products, 2- acetamido-3, 7-dihydro-5-dimethylamino-methylpyrrolo [2, 3-d] pyrimidin-4-one, and 2- acetamido-3, 7-dihydro-6-dimethylaminomethylpyrrolo [2, 3-d]-pyrimidin-4-one, in a ratio of 3: 1, respectively.