An expeditious and efficient synthesis of symmetrical tris (indolyl) methanes under catalyst-free conditions in fluorinated alcohols

S Khaksar, SM Vahdat, M Gholizadeh…

Index: Khaksar, Samad; Vahdat, Seyed Mohammad; Gholizadeh, Mahnaz; Talesh, Saeed Mohammadzadeh Journal of Fluorine Chemistry, 2012 , vol. 136, p. 8 - 11

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Citation Number: 5

Abstract

Hexafluoro-2-propanol (HFIP) is explored as an effective medium for the synthesis of symmetrical tris (indolyl) methanes through the reaction of indole derivatives with orthoesters at room temperature. The solvent (HFIP) can be readily separated from reaction products and recovered in excellent purity for direct reuse.