Controllable Synthesis of Pyrazolo [3, 4-b] pyridines or Substituted Malononitrile Derivatives through Multi-Component Reactions in Ionic Liquid

X Zhang, X Li, X Fan, X Wang, J Wang, G Qu

Index: Zhang, Xinying; Li, Xiaoyan; Fan, Xuesen; Wang, Xia; Wang, Jianji; Qu, Guirong Australian Journal of Chemistry, 2009 , vol. 62, # 4 p. 382 - 388

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Citation Number: 8

Abstract

Abstract A multi-component reaction of aldehyde, malononitrile, and 5-amino-3-methyl-1- phenylpyrazole was carried out smoothly in [bmim][BF 4] without any added catalyst. Through this reaction, pyrazolo [3, 4-b] pyridines or substituted malononitrile derivatives were obtained conveniently and controllably at different temperatures. The ionic liquid used can be easily recovered and efficiently reused for at least five runs.