Structure—activity relationships for enhancement of paracellular permeability by 2??alkoxy??3??alkylamidopropylphosphocholines across Caco??2 cell monolayers
DZ Liu, SL Morris??Natschke, LS Kucera…
Index: Liu, Dong-Zhou; Morris-Natschke, Susan L.; Kucera, Louis S.; Ishaq, Khalid S.; Thakker, Dhiren R. Journal of Pharmaceutical Sciences, 1999 , vol. 88, # 11 p. 1169 - 1174
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Citation Number: 21
Abstract
Abstract The oral route is the preferred route of delivery for a large number of drug molecules. However, the intestinal epithelium presents a formidable barrier for delivery of drugs into systemic circulation. Phospholipids are among compounds that enhance the absorption of drugs across the intestinal epithelium. In this paper, we describe structure– activity relationships for phospholipid derivatives as enhancers of paracellular ...
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