Journal of the American Chemical Society

Synthetic Approaches to Ipecac Alkaloids. I. A New Synthesis of 2-Pyridones1a, b

JA Berson, T Cohen

Index: Berson; Cohen Journal of the American Chemical Society, 1956 , vol. 78, p. 416

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Citation Number: 20

Abstract

Although construction of the gross skeletoii of emetine (I), the principal base of ipecac, has been recorded in syntheses of (i) C-noremetine, 2bJ (ii) a mixture of diastereomers of the structure I which was dehydrogenated to d, l-rubremetine, 2c and (iii) a mixture of diastereomers from which emetine itself was isolated, 2a none of these studies was concerned with the formidable problem of stereochemistry and sterically controlled ...