One-pot synthesis of 4 (3H)-quinazolinones from azides, alkynes, anilines, and carbon monoxide

Y Shen, C Han, S Cai, P Lu, Y Wang

Index: Shen, Yang; Han, Chao; Cai, Shuying; Lu, Ping; Wang, Yanguang Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5671 - 5673

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Citation Number: 8

Abstract

A one-pot synthesis of 4 (3H)-quinazolinones from terminal alkynes, sulphonyl azide, o- iodoanilines, and carbon monoxide has been developed. This cascade process includes the copper-catalyzed three-component reaction of alkyne, azide and amine, the palladium- catalyzed carbonylation, and the Lewis acid catalyzed hydrolysis of sulfonamide.