Tetrahedron 2018-02-23

A practical method for heterogeneously-catalyzed Mizoroki–Heck reaction: Flow system with adjustment of microwave resonance as an energy source

Tomohiro Ichikawa, Masahiro Mizuno, Shun Ueda, Noriyuki Ohneda, Hiromichi Odajima, Yoshinari Sawama, Yasunari Monguchi, Hironao Sajiki

Index: 10.1016/j.tet.2018.02.044

Full Text: HTML

Abstract

The microwave-assisted and continuous-flow Mizoroki–Heck reaction using a heterogeneous palladium catalyst supported on the anion-exchange resin DIAION WA30 (7% Pd/WA30) is described. The microwave resonance is finely adjusted to 2.4 GHz according to the electric permittivity of the reaction medium for efficient heating. Organic solvents, such as acetonitrile, N,N-dimethylacetamide, and toluene, can be sufficiently heated even with a low intensity of microwave irradiation in a 7% Pd/WA30-packed, glass tube-shaped catalyst cartridge, which was designed based on the electric permittivity of the solvents. The catalyst cartridge can be continuously reused at least 5 runs without exchange.

Latest Articles:

Synthesis of chiral α-amino anilides via a DMEDA-promoted selective C─N coupling reaction of aryl halides and α-aminoamides

2018-04-11

[10.1016/j.tet.2018.03.003]

A site isolation-enabled organocatalytic approach to enantiopure γ-amino alcohol drugs

2018-04-11

[10.1016/j.tet.2018.04.022]

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin

2018-04-10

[10.1016/j.tet.2018.02.051]

Process design methodology for organometallic chemistry in continuous flow systems

2018-04-07

[10.1016/j.tet.2018.04.020]

Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

2018-04-07

[10.1016/j.tet.2018.04.012]

More Articles...