European Journal of Organic Chemistry 2018-03-24

Nucleobases Having M–C Bonds: An Emerging Bio‐Organometallic Field

Alba Collado; Mar Gómez‐Gallego; Miguel A. Sierra

Index: 10.1002/ejoc.201800135

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Abstract

The combination of nucleobases with metals has been a subject of study for the last half century. The understanding of some biological processes and, especially, of the mode of action of metal‐based antitumor drugs, has focused the advances in the field on metal coordination complexes derived from the presence of lone pair N or O atoms in the nucleobase skeleton. This microreview offers a different view, covering the synthetic strategies reported for the preparation of metal complexes derived from nucleobases, nucleosides, and nucleotides and containing at least one M–C bond.

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