Methotrexate analogs. 19. Replacement of the glutamate side-chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and …

A Rosowsky, RA Forsch, JH Freisheim…

Index: Rosowsky, Andre; Forsch, Ronald A.; Freisheim, James H.; Moran, Richard G.; Wick, Michael Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 600 - 604

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Citation Number: 34

Abstract

(AMT), l" we were interested in preparing and evaluating the biological activity of compounds in which the y-carboxyl of the glutamate moiety is replaced by another acidic group. Replacement of C02H by SOsH seemed attractive because of the ready availability ...

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