Organic Process Research & Development 2018-03-29

Exemplifying Prediction of Preferred Coupling Partners in Developing a Buchwald–Hartwig Coupling for the Synthesis of a c-Kit Inhibitor

Quanbing Wu, Xin Xiong, Yudong Cao, Lijuan He, Zhongbo Fei

Index: 10.1021/acs.oprd.8b00043

Full Text: HTML

Abstract

Two convergent syntheses for compound 1 are described that apply Buchwald–Hartwig coupling as the key step. This development work provides a direct comparison of the coupling results from different coupling partners and illustrates that more efficiency can be achieved by selecting the right coupling partners.

Latest Articles:

Palladium-Catalyzed C–O Coupling of a Sterically Hindered Secondary Alcohol with an Aryl Bromide and Significant Purity Upgrade in the API Step

2018-04-12

[10.1021/acs.oprd.8b00022]

UV PhotoVap: Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry

2018-04-12

[10.1021/acs.oprd.8b00037]

Novel Process for Preparation of Tetrabenazine and Deutetrabenazine

2018-04-10

[10.1021/acs.oprd.8b00011]

Ir-Catalyzed Borylation as an Efficient Route to a Nicotine Hapten

2018-04-09

[10.1021/acs.oprd.8b00053]

Crystallization of a Metastable Solvate and Impact of the Isolation Method on the Material Properties of the Anhydrous Product

2018-04-09

[10.1021/acs.oprd.8b00062]

More Articles...