Advanced Synthesis and Catalysis 2018-04-18

One‐pot Construction of Difluorinated Pyrrolizidine and Indolizidine Scaffolds via Copper‐Catalyzed Radical Cascade Annulation

Xiaoyang Wang; Miao Li; Yanyan Yang; Minjie Guo; Xiangyang Tang; Guangwei Wang

Index: 10.1002/adsc.201701643

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Abstract

A convenient approach to the synthesis of diverse difluorinated nitrogen‐containing polycycles via a copper‐catalyzed radical cascade annulation of amine‐containing olefins and ethyl bromodifluoroacetate was developed. Three new bonds, including a −CF2 and two C−N bonds, are forged simultaneously in this strategy. Through this strategy, a series of difluorinated pyrrolizidine and indolizidine derivatives have been conveniently synthesized in good yields.

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