Synthesis, conformational analysis, and antiarrhythmic properties of 7-benzyl-3-thia-7-azabicyclo [3.3. 1] nonan-9-one, 7-benzyl-3-thia-7-azabicyclo [3.3. 1] nonane …

BR Bailey III, KD Berlin, EM Holt…

Index: Bailey III; Berlin; Holt; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 758 - 767

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Citation Number: 42

Abstract

6 but as an oil, which was converted to perchlorate 2b (82%). Recrystallization of crude 2b from ethanol gave a product of high purity, which produced consistent biological screening data. Alcohol 3a was prepared (81%) by the addition of 2 equiv of phenylmagnesium bromide to ketone 1 in ether in approximately 2 h. Recrystallization of crude 3a from ethanol gave only one pure isomer. Consequently, the addition appeared to be very ...