Development of nonproprietary phosphine ligands for the Pd-catalyzed amination reaction

RA Singer, M Doré, JE Sieser, MA Berliner

Index: Singer, Robert A.; Dore, Michael; Sieser, Janice E.; Berliner, Martin A. Tetrahedron Letters, 2006 , vol. 47, # 22 p. 3727 - 3731

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Citation Number: 101

Abstract

A new family of pyrazole and bi-pyrazole phosphine ligands are reported that perform efficiently in the Pd-catalyzed amination reaction. Of the ligands screened, ligand 1 emerged as the most compatible for couplings involving both primary and secondary amines with typical yields of 84–99%.