Detection of Rocuronium in Whole Blood Using a Lipid‐Bonded Conducting Polymer and Porous Carbon Composite Electrode

Saeromi Chung; Boo‐Young Hwang; M. H. Naveen; Yoon‐Bo Shim

Index: 10.1002/elan.201800102

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Abstract

Rocuronium is a neuromuscular blocking agent used in anesthesia to facilitate tracheal intubation by muscle relaxation. A fast and sensitive amperometric sensor was developed for the detection of rocuronium in human whole blood samples. The sensor probe was fabricated using phosphatidylinositol lipid (PI) bonded 3′‐(2‐aminopyrimidyl)‐2,2′ : 5′,2′′‐terthiophene and porous carbon, which revealed the enhanced response to the rocuronium oxidation. The modified sensor layers were characterized by electrochemical and surface analysis experiments. The experimental parameters affecting the rocuronium analysis were studied in terms of PI concentration, amount of porous carbon, pH, temperature, and interferences. A dynamic range was observed between 0.025 to 10 μg/mL with the detection limit of 3.83±0.21 ng/mL. The reliability of proposed sensor was successfully demonstrated through the detection of rocuronium in clinical samples without pre‐treatment.