2, 4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 11. Quinolylmethyl analogs with basic substituents conveying specificity

SE Davis, BS Rauckman, JH Chan…

Index: Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942

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Citation Number: 18

Abstract

A series of nine 2, 4-diamino-5-[6-(or 7-) quinolylmethyl] pyrimidines has been prepared by condensations of qui-nolinecarboxaldehydes with 0-anilinopropionitriles, followed by treatment with guanidine. All compounds had basic or methoxy substituents at the 2-or 4- positions of the quinoline ring. All of the 6-quinolylmethyl derivatives were highly inhibitory against Escherichia coli dihydrofolate reductase (DHFR), provided that an &substituent ...