Terminal alkynes as keto-methyl equivalent toward one pot synthesis of 1, 5-benzodiazepine derivatives under catalysis of Hg (OTf) 2

G Maiti, U Kayal, R Karmakar, RN Bhattacharya

Index: Maiti, Gourhari; Kayal, Utpal; Karmakar, Rajiv; Bhattacharya, Rudraksha N. Tetrahedron Letters, 2012 , vol. 53, # 12 p. 1460 - 1463

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Citation Number: 20

Abstract

Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds, which possess a wide range of therapeutic and pharmacological properties. Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle-relaxant, and amnesic action. 1 These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, ...