Development of highly enantioselective new Lewis basic N-formamide organocatalysts for hydrosilylation of imines with an unprecedented substrate profile

P Wu, Z Wang, M Cheng, L Zhou, J Sun

Index: Wu, Pengcheng; Wang, Zhouyu; Cheng, Mounuo; Zhou, Li; Sun, Jian Tetrahedron, 2008 , vol. 64, # 49 p. 11304 - 11312

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Citation Number: 29

Abstract

l-Pipecolinic acid derived N-formamides have been developed as new Lewis basic organocatalysts that promote the asymmetric reduction of N-aryl ketimines using trichlorosilane as the reducing agent. The substituent on N4 of the piperazinyl backbone ...