One??Pot, Three??Component Synthesis of 1, 4, 5??Trisubstituted 1, 2, 3??Triazoles Starting from Primary Alcohols

…, J Zhang, D Fu, J Wu, S Cao

Index: Jin, Guanyi; Zhang, Jian; Fu, Dan; Wu, Jingjing; Cao, Song European Journal of Organic Chemistry, 2012 , # 28 p. 5446 - 5449

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Citation Number: 10

Abstract

Abstract A novel, one-pot, three-component approach for the synthesis of 1, 4, 5- trisubstituted 1, 2, 3-triazoles through the cycloaddition of a wide range of primary alcohols with sodium azide and active methylene ketones in the presence of N-(p-toluenesulfonyl) imidazole, tetrabutylammonium iodide, and triethylamine in DMF/DMSO has been developed.