Tetrahedron

Synthesis of thromboxane A 2 analogs—4:(±)-Dithiathromboxane A2 sodium salt

S Ohuchida, N Hamanaka, M Hayashi

Index: Ohuchida, Shuichi; Hamanaka, Nobuyuki; Hayashi, Masaki Tetrahedron, 1983 , vol. 39, # 24 p. 4273 - 4280

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Citation Number: 11

Abstract

In the preceding papers'** we have described the syn- theses of thiathromboxane A2 possessing one sulfur atom in the bicycle [3.1.1] heptane skeleton. In this article is described the total synthesis of the sodium salt 1 of dithiathromboxane A2 which contains two sulfur atoms in the main framework, bicycle-[3.l.llheptane ring.' ... In the synthesis of 1 the most important problem was the construction of 2,6 - dithiabicyclo[3.1.l]heptane skeleton. To the best of our ...