Identification of an acridine photoaffinity probe for trypanocidal action

…, A Messa, R Reid, RC Wang, CL Watkins…

Index: Firth, William J.; Messa, Andrew; Reid, Robert; Wang, Rung Chou (Charles); Watkins, Charles L; Yielding, Lerena W. Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 865 - 870

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Citation Number: 12

Abstract

Twenty-four acridine derivatives were screened for trypanocidal activity in Trypanosoma brucei in order to determine which structural features of the acridine molecule confer maximal antiparasitic activity. The syntheses of several new azidoacridine derivatives are also reported as well as an assessment of their value as possible photoaffinity probes for the study of acridine trypanocidal action. The most effective and selective acridine ...