A Case of Pictet??Spengler Revisited: Application to the Synthesis of Dihydroisocoumarins

N Choukchou??Braham, B Mostefa??Kara…

Index: Choukchou-Braham; Mostefa-Kara; Cheikh; Didi; Villemin Synthetic Communications, 2005 , vol. 35, # 2 p. 169 - 178

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Abstract

Among the different classes of natural products that have been studied for their biological activities, isocoumarins have received limited attention. Mellein (Fig. 1), an Aspergillus Mellius metabolite isolated by Nishikawa in 1933, is the first example in such a class known for presenting antibacterial activity.[1]1. Nishikawa , H. 1933. Nippon Nogeikagaku Kaishi. Aspergillus mellus yukawa. J. Agri. Chem. Soc. Japan, 9: 772–774. ... View all references [2]2. Yabuta , T. ...

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