Journal of Antibiotics 2018-03-07

Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454

Sheng Tao Bo, Zi Fei Xu, Li Yang, Ping Cheng, Ren Xiang Tan, Rui Hua Jiao, Hui Ming Ge

Index: 10.1038/s41429-018-0039-x

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Abstract

Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.

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