Total synthesis of pulchellalactam via an RCM strategy

SP Chavan, AB Pathak, AN Dhawane…

Index: Chavan, Subhash P.; Pathak, Ashok B.; Dhawane, Abasaheb N.; Kalkote Synthetic Communications, 2007 , vol. 37, # 9 p. 1503 - 1510

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Citation Number: 9

Abstract

The scarcity of effective inhibitors of protein tyrosine phosphatase has led to a search for other small molecule inhibitors. Pulchellalactam (1) has been shown to possess remarkable inhibitory action against CD45. However, because of its limited availability from the marine source, there is a need to obtain this molecule in sufficient amounts through synthetic endeavors. ... View all references reported the first total synthesis of (1) in six??steps starting from N??boc??glycine ...