Kinetic enzymatic resolution of cyclopropane derivatives

J Pietruszka, A Rieche, T Wilhelm…

Index: Pietruszka, Joerg; Rieche, Anja C. M.; Wilhelm, Thorsten; Witt, Andreas Advanced Synthesis and Catalysis, 2003 , vol. 345, # 12 p. 1273 - 1286

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Citation Number: 18

Abstract

Abstract The kinetic enzymatic resolution of various cyclopropane derivatives was systematically investigated. The study focused on synthetically useful cyclopropylmethanols (eg, 18a/j or 19a/j) as well as some rarely investigated cyclopropanols (eg, 24/25 or 27). The combination of enantioselective catalytic or diastereoselective synthesis of enantiomerically enriched compounds with enzymatic approaches ultimately led to the most convenient ...

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