Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs

P Wang, D Naduthambi, RT Mosley, C Niu…

Index: Wang, Peiyuan; Naduthambi, Devan; Mosley, Ralph T.; Niu, Congrong; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4642 - 4647

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Citation Number: 27

Abstract

Phenylpropenamides have been reported to be a class of non-nucleoside inhibitors of the hepatitis B virus (HBV). This class of compounds was explored with the objective of developing potent anti-HBV agents, with a novel mechanism of action, that could be combined with nucleos (t) ide analogs currently used to treat HBV infection. To accomplish this objective a series of substituted arylpropenamide derivatives were prepared and the E ...