Trends in Biochemical Sciences 2018-03-07

The Cytokinin-Activating LOG-Family Proteins Are Not Lysine Decarboxylases

Muhammad Naseem, Elena Bencurova, Thomas Dandekar

Index: 10.1016/j.tibs.2018.01.002

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Abstract

A conserved PGGxGTxxE motif misleads the cytokinin (CK) converting LONELY GUY enzymes to be wrongly annotated as lysine decarboxylases (LDCs). However, so far PGGxGTxxE motif-containing LDCs do not show any LDC activity. Instead, they show phosphoribohydrolase activity by converting inactive CK nucleotides into active free-base forms to invoke CK responses.

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