N??chlorination of dilantin and sorbinil

CA Lipinski, J Bordner, GC Butterfield…

Index: Lipinski; Bordner; Butterfield; Marinovic Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1793 - 1799

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Citation Number: 3

Abstract

Abstract The synthesis, stability, X-ray structural characterization and 13 C nmr shifts of N- 1′, N-3′-dichloro and N-1′-monochlorohydantoin derivatives of the anticonvulsant dilantin and the aldose reductase inhibitor sorbinil are described. These chlorinated derivatives may be involved in drug induced hypersensitivity reactions.