Thioalkylation of Meldrum's Acid: Protected alkylidene derivatives of isopropylidene malonate

M Eberle, RG Lawton

Index: Eberle, Martin; Lawton, Richard G. Helvetica Chimica Acta, 1988 , vol. 71, p. 1974 - 1982

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Citation Number: 14

Abstract

Abstract Thioalkylated Meldrum's acid is easily by treatment of Meldrum's acid with an aldehyde and thiophenol in the presence of catalytical amounts of piperidinium acetate ([RIGHTWARDS ARROW] 1–6, Table 1). The adducts 1–6 are crystalline, stable compounds and they can be caused to react directly with nucleophiles and dienes (see 3 [RIGHTWARDS ARROW] 7–12, Scheme 1). The regeneration of the parent olefin is ...