Analyst 2018-04-11

One-step isothermal detection of multiple KRAS mutations by forming SNP specific hairpins on a gold nanoshell

Chan Ho Chung, joong Hyun kim

Index: 10.1039/C8AN00525G

Full Text: HTML

Abstract

We developed a one-step isothermal method for typing mutiple KRAS mutations using designed set of primers to form a hairpin on a gold nanoshell upon being ligated by a SNP specific DNA ligase after binding of targets. As a result, we could detect as low as 20 attomoles of KRAS mutations within 1 h.

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