Synthesis

Sonogashira cross-coupling reactions and construction of the indole ring system using a robust, silica-supported palladium catalyst

E Tyrrell, L Whiteman, N Williams

Index: Tyrrell, Elizabeth; Whiteman, Leon; Williams, Neil Synthesis, 2009 , # 5 p. 829 - 835

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Citation Number: 15

Abstract

Abstract The use of a recyclable silica-supported palladium catalyst in Sonogashira couplings and indole syntheses using a range of functionalised substrates is described. The catalyst is shown to be both robust and versatile, effecting the synthesis of 2-phenylindole in quantitative yield without the need for N-protection, a copper cocatalyst, a base, or a solvent.