Organic letters

Uncatalyzed and solvent-free multicomponent process for the synthesis of biphenyl-2-carbonitrile derivatives

F Fringuelli, R Girotti, O Piermatti, F Pizzo…

Index: Fringuelli, Francesco; Girotti, Rugiada; Piermatti, Oriana; Pizzo, Ferdinando; Vaccaro, Luigi Organic Letters, 2006 , vol. 8, # 25 p. 5741 - 5744

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Citation Number: 25

Abstract

Among all the possible organometallics, tin (Stille coupling), 4 boron derivatives (Suzuki−Miyaura coupling), 5 and to a lesser extent organozinc (Negishi coupling), organomagnesium (Kumada coupling), and organosilicon reagents (Hiyama) have been the most frequently used. 3 To promote these coupling reactions, various metal catalysts have been used and particular attention has been paid to palladium complexes. 3,6 The uncatalyzed synthesis of the biphenyl system ...