Adamantylation of azoles with 1, 3-dehydroadamantane. Selective N-adamantylation of pyrazoles

GM Butov, VM Mokhov, GY Parshin, BA Lysykh…

Index: Butov; Mokhov; Parshin; Lysykh; Konyushkin; Firgang Russian Journal of Organic Chemistry, 2011 , vol. 47, # 1 p. 150 - 151

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Abstract

The main procedure for the synthesis of N-and C-adamantyl-containing pyrazoles is based on acidcatalyzed adamantylation of pyrazoles with various functional derivatives of adamantane [1–6]. However, this method ensures fairly poor yields of the target products and requires strongly acidic medium. A promising method for the preparation of N- adamantylsubstituted pyrazoles involves as initial compound strained [3.3. 1] propellane, ...

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