Development of a New α??Aminonitrile Synthesis

GH Chu, M Gu, B Gerard, RE Dolle

Index: Chu, Guo-Hua; Gu, Minghua; Gerard, Baudouin; Dolle, Roland E. Synthetic Communications, 2004 , vol. 34, # 24 p. 4583 - 4590

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Abstract

Abstract α??Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α??amino??arylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.