Regioselective ring-opening of epoxides with amines using Zn (ClO 4) 2–Al 2 O 3 as a heterogeneous and recyclable catalyst
M Maheswara, KSVK Rao, JY Do
Index: Maheswara, Muchchintala; Rao, Kummari Subba Venkata Krishna; Do, Jung Yun Tetrahedron Letters, 2008 , vol. 49, # 11 p. 1795 - 1800
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Citation Number: 25
Abstract
In this Letter, we have described a mild and efficient method for the nucleophilic ring-opening of epoxides with amines in the presence of heterogeneous catalyst zinc perchlorate–neutral alumina to afford the corresponding β-amino alcohols in excellent yields. It was observed in the absence of catalyst, the reaction did not proceed in dichloromethane even after prolonged reaction times (Scheme 1). In the presence of zinc perchlorate Zn(ClO 4 ) 2 without using alumina ...
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