Synthetic ion channel activity documented by electrophysiological methods in living cells

…, JE Huettner, R Pajewski, PH Schlesinger…

Index: Leevy, W. Matthew; Huettner, James E.; Pajewski, Robert; Schlesinger, Paul H.; Gokel, George W. Journal of the American Chemical Society, 2004 , vol. 126, # 48 p. 15747 - 15753

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Citation Number: 34

Abstract

Hydraphiles are synthetic ion channels that use crown ethers as entry portals and that span phospholipid bilayer membranes. Proton and sodium cation transport by these compounds has been demonstrated in liposomes and planar bilayers. In the present work, whole cell patch clamp experiments show that hydraphiles integrate into the membranes of human embryonic kidney (HEK 293) cells and significantly increase membrane conductance. The ...

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