A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y 12 receptor

P Bach, J Boström, K Brickmann, JJJ van Giezen…

Index: Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Van Giezen; Hovland, Ragnar; Petersson, Annika U.; Ray, Asim; Zetterberg, Fredrik Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2877 - 2881

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Citation Number: 13

Abstract

Abstract A novel series of P2Y 12 antagonists for development of drugs within the antiplatelet area is presented. The synthesis of the piperazinyl-pyridine urea derivatives and their structure–activity relationships (SAR) are described. Several compounds showed P2Y 12 antagonistic activities in the sub-micromolar range.