Quinol fatty alcohols as promoters of axonal growth

M Hanbali, M Vela-Ruiz, D Bagnard, B Luu

Index: Hanbali, Mazen; Vela-Ruiz, Marta; Bagnard, Dominique; Luu, Bang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2637 - 2640

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Citation Number: 6

Abstract

The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2, 5-dimethoxyphenyl) pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n= 15), shows the most potent promotion of axonal growth in the presence of both permissive and non- permissive naturally occurring substrates such as Sema3A and myelin proteins.