New cysteamine (2-chloroethyl) nitrosoureas. Synthesis and preliminary antitumor results

JC Madelmont, D Godeneche, D Parry…

Index: Madelmont, J. C.; Godeneche, D.; Parry, D.; Duprat, J.; Chabard, J. L.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1346 - 1350

Full Text: HTML

Citation Number: 31

Abstract

(2-Chloroethyl) nitrosoureas, a class of very active antitumor agents, are of interest for the treatment of glioblastoma, Hodgkin's disease, non-Hodgkin's lymphoma, bronchial carcinoma, and gastric cancers.'-5 To date the most widely used in cancer chemotherapy are BCNU, CCNU, and MeCCNU. Among the several compounds of this important series, the more effective agents chlorozotocin, ACNU, MeCCNU, and RFCNU have undergone ...