Iron-catalyzed cross-coupling of unactivated secondary alkyl thio ethers and sulfones with aryl Grignard reagents
SE Denmark, AJ Cresswell
Index: Denmark, Scott E.; Cresswell, Alexander J. Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12593 - 12628
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Citation Number: 25
Abstract
The first systematic investigation of unactivated aliphatic sulfur compounds as electrophiles in transition-metal-catalyzed cross-coupling are described. Initial studies focused on discerning the structural and electronic features of the organosulfur substrate that enable the challenging oxidative addition to the C (sp3)–S bond. Through extensive optimization efforts, an Fe (acac) 3-catalyzed cross-coupling of unactivated alkyl aryl thio ethers with aryl ...
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