Thromboxane A2 synthetase inhibitors. 2. Syntheses and activities of tetrahydronaphthalene and indane derivatives

…, N Kanaya, H Kubo, S Ashida, F Ishikawa

Index: Kanao; Watanabe; Kimura; Saegusa; Yamamoto; Kanno; Kanaya; Kubo; Ashida; Ishikawa Journal of medicinal chemistry, 1989 , vol. 32, # 6 p. 1326 - 1334

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Citation Number: 29

Abstract

IV CV 4151 apeutic agents for ischemic heart disease, thromboembolic disorders, and cerebral circulatory disorders. 2 It has been theorized that the complete and long-lasting suppression of TU z is necessary in the ischemic heart disease because of the highly potent biological activities of TXA2. Thus potent and long-lasting agents will be of value in the treatment of ischemic heart disease. Many potent compounds have been reported: 4-[2-(l- ...