Tetrahedron Letters

Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams

FI McGonagle, L Brown, A Cooke, A Sutherland

Index: McGonagle, Fiona I.; Brown, Lindsay; Cooke, Andrew; Sutherland, Andrew Tetrahedron Letters, 2011 , vol. 52, # 18 p. 2330 - 2332

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Citation Number: 14

Abstract

A microwave-promoted three-step tandem process for the synthesis of bicyclic γ-lactams is developed. In all cases examined this led to significantly faster tandem processes producing the bicyclic γ-lactams more cleanly and reproducibly compared to standard thermal conditions.

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