Synthesis and photochemical activity of designed enediynes

…, G Plourde, AD Purohit, JK Wyatt, G Hynd…

Index: Jones; Wright; Plourde II; Purohit; Wyatt; Hynd; Fouad Journal of the American Chemical Society, 2000 , vol. 122, # 40 p. 9872 - 9873

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Citation Number: 67

Abstract

The enediynes are a growing class of antitumor agents, with spectacular biological profiles. 1 Nearly 20 discrete enediynes have been discovered, and clinical trials of a number of these are ongoing. 2 While the in vitro and in vivo effectiveness of enediynes against certain cancers is unquestioned, the exact mechanism (s) of biological activity remains to be fully resolved. Enediynes per se are biologically inactive, but undergo cycloaromatization ...