Phenylalkyl isothiocyanate-cysteine conjugates as glutathione S-transferase stimulating agents

GQ Zheng, PM Kenney, LKT Lam

Index: Zheng, Guo-qiang; Kenney, Patrick M.; Lam, Luke K. T. Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 185 - 188

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Citation Number: 36

Abstract

T o develop analogues of phenylalkyl isothiocyanate with less toxicity and better biological activity, two water-soluble phenylalkyl isothiocyanate-cysteine conjugates, S-[N-benzyl (thiocarbamoyl)]-cysteine (1) and S-[N-(bphenyl-propyl)(thiocarbamoyl)]-cysteine (2), were synthesized. The induction of increased activity of the detoxifying enzyme glutathione S- transferase by the conjugates and their parent compounds was determined and compared ...